Abstract: With the rapid development of information technology, it is difficult for enterprises to rely on their own resources to carry out innovation activities and to make rapid responses to personalized and diversified needs of consumers. Although enterprises can carry out innovation activities through cooperation, the complex environment enhances the instability and reduces the breadth and depth of cooperative innovation. While numerous studies have examined the issues of inter-enterprise cooperation innovation in supply chain, few have been specifically conducted on the mechanism of inter-enterprise cooperation innovation in integrated supply chain (ISC). With the deep integration of supply chain, Internet and Internet of Things, inter-enterprise cooperation innovation in ISC has become an important way to create new business models and develop new markets. Inter-enterprise cooperation innovation in ISC is a process of interaction among degree of integration, knowledge collaboration ability and cooperative innovation performance. Hierarchical multiple regression and structural equation modeling are used to investigate the static mechanism of inter-enterprise cooperation innovation in ISC with SPSS and AOMS software. On this basis, B-Z reaction model in complex system theory is applied to analyse the dynamic evolution mechanism. The results of statistical analyses of 211 effective questionnaires indicate that degree of integration and knowledge synergy ability have a positive impact on the cooperative innovation performance in ISC. In the short-term, the effect of degree of integration on innovation performance is very obviously. In the long run, under the influence of the different relationship quality of ISC, knowledge synergy ability plays a vital role in the improvement of cooperative innovation performance. This study adds to the cooperation innovation literature by analyzing inter-enterprise cooperation innovation in ISC, which could help enterprise managers and policy makers take suitable measures to improve the success rate of cooperative innovation and thereby improve the cooperative innovation performance in ISC. This research also enriches the methodology of cooperative innovation system and extends the applications of complex system theory in the paradigm of ISC.

Key words: complex system theory, integrated supply chain, cooperative innovation, B-Z reaction model